Reagents promise more detection stability in LC/MS

Acetic acid, one of Thermo's Optima LC/MS reagents, is available in 1ml ampoules

THREE new liquid chromatography/mass spectrometry (LC/MS) grade reagents from Thermo Fisher are said to exhibit the lowest ionic metal content, in order to minimise background noise and enhance MS detection.

The new additions to the Optima range are acetic acid, ammonium acetate, and ammonium formate. Thermo says that they will improve chromatographic peak shape and provide stable analyte signals in an MS detector.

Ammonium acetate and ammonium formate are volatile salts, used in LC/MS to improve ionisation in electrospray-ionisation mass spec (ESI-MS). Acetic acid, in contrast, enhances chromatographic separation under acid conditions.

The minimised metal ion content limits mass adduct formation, and the low levels of impurity help to extend column life.

Acetic acid is available in 1ml glass ampoules, to maintain freshness and speed of application when preparing aqueous and organic mobile phases.


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