CRYSTALLISATION studies and screening of polymorphs needs stable sub-ambient temperatures, traditionally provided by ice baths and jacketed reaction vessels.
DrySyn Snowstorm delivers stable low temperatures for crystallisation and polymorph studies
This approach can be messy in the laboratory, requires a supply of ice, and is limited to temperatures around freezing (0C). It also demands close supervision to maintain temperature stability.
The modern alternative is to use a reaction systems such as Asynt DrySyn SnowStorm along with a suitable chiller/circulator. SnowStorm is available in a choice of configurations to provide controlled cooling for sub-ambient chemistry.
The system promises accurate, stable temperature control down to -50C and up to +150C, and is available in two models.
SnowStorm One accommodates a single standard round-bottomed flask from 50ml to 1000ml. SnowStorm Multi takes up to three round bottom flasks from 25ml to 100ml, or up to 39 vials in parallel.
Both types deliver agitation using a powerful magnetic stirrer.
Because DrySyn SnowStorm units deliver a stable controlled temperature, constant supervision is not required and, says the company, overnight runs can be performed with complete confidence.